John R Regan, PHD

John R Regan, PHD

Associate Professor

Department : Chemistry & Biochemistry

Email : john.regan@manhattan.edu

Phone : 718-862-7324

Office : HAY 401A

Education

PHD, University of Pittsburgh
BA, U. of California San Diego

About

My many years of experience in the private sector - pharmaceutical drug discovery research – taught me the value of combining theoretical with practical knowledge. For example, we can memorize that aluminum has thirteen electrons, but this knowledge has limited practical applications. On the other hand, knowing why we recycle aluminum despite the fact it’s one of the most abundant elements on the earth’s surface is more practical information. My teaching and research style gravitate towards a more nuanced understanding of the physical sciences – theoretical merged with practical. Therefore, a balanced comprehension of our world, especially the chemical components, will greatly serve the scientist-citizen of the 21st Century.

Research

My student-directed research fits under the marquee of “Environmental Chemistry.” I focus on green organic chemistry. Specifically our students examine (i) remediation of contaminated water using naturally occurring organic molecules, (ii) new and more environmentally friendly ways to perform undergraduate organic reactions and (iii) innovative technology for recycling chemical reagents that historically have been discarded after use.

Publications & Professional Activities

Student-Directed Presentations and Posters

  • “A Green Approach to Organic Synthesis: New Applications to Used Polystyrene-Containing Chemical Reagents” M. Dzikowski and J. Regan, Undergraduate Research Symposium, City College of New York, CUNY, NY (April 2013)
  • “A Green Synthesis of the Fragrance Berryflor” N. Yu and J. Regan, Undergraduate Research Symposium, City College of New York, CUNY, NY (April 2013)
  • “Investigation of Carnitine Analogs as Potential Cancer Therapies” D. DaCosta, A. Fernandez, J. Regan, R. Sullivan. American Chemical Society 244th National Meeting, Philadelphia, PA, CHED-264 (August 2012)
  • “Polymer-Supported Chemical Reagents as a New Tool for Undergraduate Chemical Laboratories” C. Hogan and J. Regan. Undergraduate Research Symposium, SUNY Old Westbury, NY (May 2012)
  •  “The Physical Requirements Necessary for Optimum Performance of Insoluble Polystyrene-bound Chemical Reagents vs. Dissolved Reagents” C. Graham, C. Hogan and J. Regan, 20th Annual Statewide CSTEP Student Conference, Sagamore Resort, NY (April 2012)

Publications 

  • “Non-steroidal dissociated glucocorticoid agonists: indoles as A-ring mimetics and function-regulating pharmacophores” R. Betageri, T. Gilmore, D. Kuzmich, T. Kirrane, J. Bentzien, D. Wiedenmayer, Y. Bekkali, J. Regan, A. Berry, B. Latli, A. Kukulka, T. Fadra, R. Nelson, S. Goldrick, L. Zuvela-Jelaska, D. Souza, J. Pelletier, R. Dinallo, M. Panzenbeck, C. Torcellini, H. Lee, E. Pack, C. Harcken, G. Nabozny, D. Thomson. Bioorg. Med. Chem. Letters, 21, 6842 (2011)
  • “Recent Developments in Glucocorticoid Receptor Agonists” J. Regan, H. Razavi and D. Thomson. Ann. Reports Medicinal Chemistry, 43, 141 (2008)
  • “The Medicinal Chemistry of Agents Targeting the Nuclear Hormone Receptor” J. Regan. Current Topics Medicinal Chemistry, 8, 727 (2008)
  • “New Modifications to the Area of Pyrazole-Naphthyl Urea-Based p38 MAP Kinase Inhibitors That Bind to the Adenine/ATP Site” N. Moss, S. Breitfelder, R. Betageri, P.F. Cirillo, T. Fadra, E. R. Hickey, T. Kirrane, R.R. Kroe, J. Madwed, R. M. Nelson, C. A. Pargellis, K. C. Qian, J. Regan, A. Swinamer and C. Torcellini. Bioorganic Med. Chem. Letters 17, 4242 (2007)
  • “Quinol-4-ones as Steroid A-Ring Mimetics in Non-Steroidal Dissociated Glucocorticoid Agonists” J. Regan, T.W. Lee, R.M. Zindell, Y. Bekkali, J. Bentzien, T. Gilmore, A. Hammach, T.M. Kirrane, A.J. Kukulka, D. Kuzmich, R.M. Nelson, J.R. Proudfoot, M. Ralph, J. Pelletier, D. Souza, L. Zuvela-Jelaska, G. Nabozny and D.S. Thomson. J. Med. Chem., 49, 7887 (2006).

Courses Taught/Teaching

CHEM 319 - Organic Chemistry

CHEM 323 & CHEM 324 - Organic Chemistry Lab

SCI 203 & 204 - Topics in Science